CASP8 and neuroblastoma: As caspase 8 mRNA levels do not differ significantly between A2780 and CP70, the low caspase 8 protein levels in CP70 are likely to be caused by decreased translation of caspase 8 protein rather than decreased transcription through methylation or genetic alterations that occur in neuroblastoma (Teitz et al, 2000; Takita et al, 2001) and in other solid tumours (Kim et al, 2003; Soung et al, 2005).