IGFBP2 and Familial prostate cancer: The IGFBP-2 is considered a key factor in prostate cancer progression (Degraff et al, 2009) with levels of IGFBP-2 being elevated in patients with CaP, both in serum where levels correlate with those of PSA (Kanety et al, 1993) and in the tumours (Bubendorf et al, 1999).