FHIT and cancer: Compared with never-smokers, current smokers who are cancer-free, but not necessarily disease-free, are also reported to have a higher prevalence of methylated forms of the TSGs fragile histidine triad (FHIT) and O-6-methylguanine-DNA methyltransferase (MGMT) in bronchial lavages and plasma, respectively (Kim et al, 2004; Belinsky et al, 2005).