SERPINA1 and hypersensitivity vasculitis: In 1995 Dowd et al (University of Louisville School of Medicine, Louisville, Kentucky) reported a case of to "a 49-year-old man, with a PI*ZZ genotype and AAT serum of 24 mg/d, suffering from extensive cutaneous leukocytoclastic vasculitis, with multiple recurrences partially controlled with colchicine, prednisone, plasma infusions and plasma-exchange therapy" [61].