Whereas NFs are altered in many neurodegenerative disorders including Amyotrophic Lateral Sclerosis (ALS), Parkinson's, Alzheimer's and Charcot-Marie-Tooth diseases [7], the generalized aggregation of other neuronal and non neuronal Intermediate Filaments (IFs) [8,9] in GAN points to a central role of the GAN gene in maintaining cytoskeletal architecture. The gene discussed is GAN; the disease is amyotrophic lateral sclerosis.