In female rats, HF diet induced an increase of proteins involved in the adrenergic control of lipolytic pathway, with a higher α2/β3-AR ratio (Table 7) and a lower LPL/HSL ratio (0.62 ± 0.15 for HF females and 1.75 ± 0.39 for HF males, p < 0.05), contributing to a lesser accumulation of fat in the visceral region of female rats. The gene discussed is ADRB3; the disease is hydrops fetalis.