To this end, we divided the four factors to two groups, based on their published functional interactions in breast tumor cells: Group 1 - The inflammatory cytokines TNFα & IL-1β, which promote the release of CCL2 & CCL5 by breast tumor cells; Group 2 - The inflammatory chemokines CCL2 & CCL5, whose release by malignant breast cells is increased by TNFα and IL-1β (Please refer to Additional Files 1 and 2, as well as to references [65-70]. Here, TNF is linked to breast neoplasm.