This higher Akt-mTOR-S6k signaling was unexpected, since phosphorylations at relevant sites of Akt, mTOR, 4E-BP, S6k and S6k's downstream substrate ribosomal protein S6 are decreased in muscles of different animal models of sepsis [10], [31], [32] and burn injury [33]. The gene discussed is AKT1; the disease is Sepsis.