FOXO3 and Hyperinsulinemia: Moreover, we have recently found a similar occurrence in human glucose-induced hyperinsulinemia showing decreased skeletal muscle atrogin1 and MuRF1 mRNA in concert with increased FoxO1 and unchanged FoxO3 mRNA (Nedergaard, Jespersen, Schjerling and Kjaer, unpublished) similar to results from rats [59].