Furthermore, analysis of cytokine mRNA in EM skin biopsies from patients without concomitant EM-associated symptoms, have shown expression of both IFN-γ and IL-10, whereas cytokine analysis in skin of EM-patients with such symptoms have additionally shown a large number of macrophage-derived pro-inflammatory cytokines, such as TNF-α, IL-1β and IL-6 [23]. This evidence concerns the gene IL10 and erythema multiforme.