In view of the fact that the clinicopathological data we obtained previously from a large number of samples, which included breast cancer, gastric cancer and colorectal carcinoma, indicated that predominant nuclear staining of LRP16 in tumor cells is significantly linked to high-risk prognostic indices and short survival term [32], [39], [40], we proposed that the aberrant nuclear accumulation of LRP16 would be a common mechanism employed by tumor cells by which NF-κB was excessively activated. Here, MACROD1 is linked to breast cancer.