TRPV1 and hepatitis A virus infection: To test the role of TRPV1 in this model, we usedvanilloid receptor knockout (TRPV1−/− or VR1-KO) mice.VR1-KO mice developed hepatitis in response to ConA as indicated by increase inAST levels, which was similar to that seen in ConA-injected wild-type (WT) mice(Fig. 6A).