SCAD is anFAD-linked dehydrogenase, and a defect in SCAD function, due to misfoldingand defective interaction with functional partners e.g. electron transferflavoprotein (ETF), may thus lead to the production of superoxides in proximityto sites of semi-flavone production. This evidence concerns the gene ACADS and short chain acyl-CoA dehydrogenase deficiency.