For instance, expression of protocadherin 21 (PCDH21) is decreased by 68.4% in human psoriasis (FDR-adjusted P  = 6.62×10−37), but the mouse ortholog Pcdh21 was in fact elevated 1.5-fold in K5-Tie2 lesions (P = 0.025), 54.2-fold in IMQ lesions (P = 2.43×10−7), 5.2-fold in K14-AREG ear lesions (P = 1.1×10−3), 24.9-fold in K14-AREG tail lesions (P = 1.48×10−6), 7.4-fold in K5-Stat3C lesions (P = 3.73×10−6), and 22.5-fold in K5-TGFβ1 lesions (P = 4.8×10−4) (Figure 5B and Figure S4). The gene discussed is CDHR1; the disease is psoriasis.