KRT5 and inborn error of immunity: This disparity between K5-Tie2 and IMQ phenotypes relative to other mouse models was also evident based upon inspection of KEGG pathway terms associated with transcripts elevated in human psoriasis (e.g., primary immunodeficiency, natural killer cell mediated cytotoxicity, toll-like receptor signaling pathway, cytokine-cytokine receptor interaction and leukocyte adhesion; see Figure S6).