The psoriasis phenotypes evaluated in this study were generated on outbred, inbred and hybrid genetic backgrounds, including outbred CD1 mice (K5-Tie2), the inbred strain C57BL/6 (IMQ), as well as hybrid FVB/NCrIBR (K14-AREG), FVB/NHsd (K5-Stat3C), and ICR/B6D2 mice (K5-TGFβ1). The gene discussed is TEK; the disease is psoriasis.