KRT5 and psoriasis: Most notably, there was disparity between the K5-Tie2 and IMQ phenotypes relative to other mouse models, with respect to psoriasis-increased genes with immune-associated gene ontology terms, such as response to virus, response to lipopolysaccharide, response to cytokine stimulus, cellular defense response, innate immune response and positive regulation of αβ T-cell proliferation (Figures 6 and 8).