It was therefore significant, in the present study, to observe that gene expression signatures of mouse psoriasiform phenotypes diverged with respect to immune-associated transcripts, with three phenotypes more closely mirroring clinical psoriasis (i.e., K14-AREG, K5-Stat3C and K5-TGFβ1) as compared to two others (i.e., K5-Tie2 and IMQ). This evidence concerns the gene KRT5 and psoriasis.