Particularly noteworthy is the significantly stronger association of ANG II to HDL-cholesterol in children, mechanisms which might involve translocation of scavenger receptor type-BI (SR-BI) in the adipose tissue [38], or angiotensin-converting enzyme (ACE) polymorphisms that were recently linked to components of the metabolic syndrome including HDL-cholesterol [39], both of which require further investigation. The gene discussed is ACE; the disease is metabolic syndrome.