MDM2 and glioblastoma: As shown in Figure 1E, U87MG cells showed a time-dependent increase of apoptosis induced by nutlin-3a (from 3.3 to 27% at 24 and 96 hours, respectively) when compared to DMSO vehicle control, whereas no apoptosis was observed in T98G cells, suggesting resistance to MDM2 inhibition in glioblastoma cell lines with mutant p53.