Generation of the amyloid β- peptide (Aβ) from the amyloid precursor protein (APP) by β- and γ-cleavage followed by seeded aggregation of Aβ is widely believed to be the initiating event in the pathogenesis of AD [3] resulting in sustained deposition of Aβ in brain parenchyma and cerebral blood vessels [4]. Here, APP is linked to Alzheimer disease.