The normalized protein levels in BC vs. normal tissue were as follows: OPN, 0.645±0.287 vs. 0.261±0.020 (p = 0.0286); TGFβ1, 0.837±0.114 vs. 0.300±0.195 (p = 0.0286); VEGFA, 0.678±0.183 vs. 0.295±0.133 (p = 0.05); CDKN2A, 0.687±0.157 vs. 0.429±0.088 (p = 0.0286); HRAS, 0.663±0.258 vs. 0.420±0.121 (p = 0.1143); p53, 0.760±0.167 vs. 0.448±0.295 (p = 0.2000; Mann-Whitney U test). The gene discussed is SPP1; the disease is breast cancer.