CSF3 and Decreased total neutrophil count: The dose-limiting toxicity was, as expected, myelosuppression, with G3-4 neutropenia occurring in 18.5% and 22% of the patients of arm A and B, respectively, with grade 3-4 neutropenic fever observed in 3 (5.5%) patients of arm A, and in 2 patients (4.0%) of arm B, in whom the administration of G-CSF was required.