Adding basal insulin to 0/1 OAD was associated with a significantly lower risk of hypoglycaemia versus adding basal insulin to 2 OADs [−0.546 (−0.860 to −0.232), p = 0.001; Cochran Q = 5.660, p = 0.226 and I2 = 29.332, figure 5A). The gene discussed is INS; the disease is Hypoglycemia.