The results from this pooled analysis were supported by a meta-analysis of five eligible studies from the trial cohort in which the OR of achieving glycaemic goals at week 24 was significantly higher and risk of symptomatic hypoglycaemia was significantly lower for patients taking MET alone before initiation of basal insulin compared with those taking an SU alone or in combination with MET. The gene discussed is INS; the disease is Hypoglycemia.