For example: (i) over expression of non-cleavable FasL in the cornea triggers accelerated transplant rejection [47], and (ii) tumor cells that express a membrane-only form of FasL induce a severe ocular inflammatory response [48] Moreover, a number of studies have shown that the soluble form of FasL antagonizes the functional outcome of membrane-bound FasL [24], [25], [49], while others reported that sFasL could bind to ocular matrix proteins and thereby acquire potent apoptotic activity [26]. This evidence concerns the gene FASLG and neoplasm.