IFN-γ production in response to the rHBHAms was significantly lower in those with active TB (median: 0.2 IU/ml, IQR: 0–16.3) compared to those with remote LTBI (median: 1.4 IU/ml, IQR: 0–28.7) (p = 0.001) and subjects with past TB (median: 1.1 IU/ml, IQR: 0–17.0) (p = 0.02) (Figure 2B), and not significantly different compared to those with a recent infection (0.7 IU/ml (IQR: 0–29.5) (p = 0.052). This evidence concerns the gene IFNG and infection.