We discovered that in the 239-tumor training set, the odds-ratios of activation of src and b-catenin pathways in our high versus low-risk group were 3.42 (95% C.I. 1.89–6.18) and 2.77 (95% C.I. 1.59–4.8) respectively, while the odds-ratio for E2F3 was 0.251 (95% C.I. 0.141 – 0.446). Here, E2F3 is linked to neoplasm.