As LCA showed to be a promiscuous ligand of EphA and EphB receptor subfamilies wetested LCA activity against EphB4 phosphorylation on T47D breast cancer cellsinduced by 3 μg/ml ephrinB2-Fc, preclustered with 0.3 μg/ml of IgGFc fragment. The gene discussed is EFNB2; the disease is breast carcinoma.