Table 1A shows that ChI MAbs use the most distal VH genes, consistent with this class having the longest CDR-H3s and the highest frequency of SMs. However, inconsistent with CDR-H3 length and SMs, anti-protein (anti-viral) AcI Abs had intermediate VH gene distances whereas SAD Abs had the most proximal ones. Importantly, the AcI MAbs, only three of which use VH1-69, used distal genes overall; the average distance for 69 anti-protein (antiviral) AcI MAbs is 450 kb, suggesting that distal genes besides VH1-69 may be selected in viral infections of all types. Here, DDX41 is linked to viral infectious disease.