LMNA and progeroid syndrome: In this study, we developed zebrafish progeria and laminopathy models in three different ways: i) exogenous expression of the zebrafish version of ‘progerin’ (zProgerin) protein, ii) translational-block MO (zLMNA-MO1)-induced translational downregulation to reduce lamin A/C protein levels, and iii) splice-block MO (zLMNA-MO2)-induced cryptic splicing of LMNA, which deleted 8 amino acid residues containing the predicted site of post-translational cleavage.