LMNA and Hutchinson-Gilford progeria syndrome: As HGPS is a dominant sporadic disease caused by mutations within exon 11 of LMNA, leading to an in frame deletion of 50 amino acids from the C-terminal tail of prelamin A (Progerin/lamin A-Δ50), we first attempted to generate transgenic zebrafish expressing a form of zebrafish lamin A with a deletion of 37 amino acids i.e. a zlamin A-Δ37 (zebrafish Progerin: zProgerin) expression construct.