TGFB1 and Buschke-Ollendorff syndrome: The potential role of AEC to participate in and direct innate immunity through secretion of cytokines, such as IL-6, IL-8, and TNF-α, and growth factors such as TGF-β1, in response to this dynamic local milieu is well established, but the ability of these factors to participate in dysregulated inflammation in the setting of systemic immunosuppression and, thereby, contribute to the genesis of BOS has not been investigated in lung transplantation [11].