CD4 and hyper-IgE syndrome: Similarly, T cell immunophenotyping has been used to identify abnormalities or changes in naïve, memory, effector, activated, TH17 inflammatory T cells, regulatory T cells (CD4+CD25+FOXP3+) and recent thymic emigrant (RTE) populations for diagnosis of several combined or cellular immunodeficiencies such as severe combined immunodeficiency (SCID), Omenn syndrome, Hyper IgE syndrome (HIES), IPEX (immunodeficiency, polyendocrinopathy, enteropathy, X-linked), CVID and DiGeorge (chromosome 22q11.2 deletion) syndrome among others [74-90].