Laboratory evaluation revealed lymphopenia with a total CD45 lymphocyte count of 0.77 (see Table 2 for reference values for key lymphocyte subsets), CD3 T cells = 491 cells/uL, CD4 = 238 cells/uL, CD8 = 240 cells/uL, CD19 B cells = 60 cells/uL and NK cells == 208 cells/uL, CD4:CD8 ratio = 0.99. This evidence concerns the gene CD8A and lymphopenia.