This study examined the beneficial effect of AM on BLM-induced pulmonary fibrosis; in particular, our results indicate that AM has strong anti-inflammatory properties resulting in a reduced: (1) MPO activity, (2) cytokines and adhesion molecules expression, (3) iNOS expression, (4) the nitration of tyrosine residues (5) PAR formation, a product of PARP-1 activity, and (7) the degree of lung injury tissues in mice subjected to BLM instillation. This evidence concerns the gene NOS2 and pulmonary fibrosis.