We analysed a broad spectrum of MMPs including MMP-1, MMP-7 and MMP-13, which have been proven to be major proteases in the pathogenesis of IBD associated mucosal ulcerations [13-15,58,59], and MMP-2 and MMP-9, which have been shown to be upregulated upon mycobacterial infection [18]. The gene discussed is MMP1; the disease is inflammatory bowel disease.