Based on current clinical data in children and adults and in the absence of a reliable marker of EPS, strong consideration should be given to electively discontinuing PD in those patients who have received long-term PD (possibly more than 5 years and certainly more than 8 years) and who demonstrate risk factors for EPS, such as UF failure, a high D/P creatinine based on PET assessment, peritoneal calcifications, a persistently elevated C-reactive protein level, and recurrent or severe peritonitis, as a possible means of preventing EPS. This evidence concerns the gene CRP and peritonitis.