In this study, we found that serum fructosamine, as an indicator of glucose consumption, may be a predictor of bladder cancer, also the amino acid, hydroxylproline, as an indicator of liver fibrosis, may be a predictor of bladder cancer risk, in addition, IgE and TNF-α are also may be used as a new immunological markers of bladder cancer. This evidence concerns the gene IGHE and Hepatic fibrosis.