The investigated parameters in serum including xanthine oxidase (XO) enzyme activity (as a marker of purine metabolism), fructosamine (as a marker of abnormal glucose metabolism), lactate dehydrogenase (as a maker of glucose metabolism), hydroxylproline (as a maker of liver fibrosis), as well as total serum immunoglobulin E (IgE), tumor necrosis factor-alpha (TNF-α) and liver function enzymes including aspartate and alanine aminotransferase (AST & ALT), total proteins and free amino acids were also measured in serum. The gene discussed is XDH; the disease is Hepatic fibrosis.