SLC6A4 and Anxiety: Others have previously shown that both systemic and local (intra-amygdala) administration of mCPP increases anxiety levels in rodents, indicating that these receptors - possibly in the basolateral amygdala - are responsible for the anxiogenic effect of mCPP [29,30].We also replicated previous findings from our lab showing that SERT -/- mice exhibit increased baseline anxiety-like behaviors in the open field test (for a review, see [1]).