In the present study, expression of CD44 extracellular domain, Zo-1, occludin, MMP-7, and laminin-5γ2 in association with beta-catenin nuclear localization, and levels of sialyl LeX were immunohistochemically investigated along with tumor budding in UC-associated and sporadic colon carcinomas, with the aim of elucidating differences in mechanisms of invasion and biological behavior between the two types of colon carcinomas in relation to prognoses. This evidence concerns the gene CD44 and colon carcinoma.