SIRT1 and cancer: There is a discrepancy in the literature regarding the role of SIRT1 in cancer.7, 8, 24 After investigating the effect of SIRT1 in several cancer types, Stunkel et al34 concluded that the function of SIRT1 in cancer is cell-context-dependent and that the role of SIRT1 can be independent of its deacetylase function.