TP53 and heart failure: When SIRT3 is overexpressed in cardiomyocytes, it increases stress resistance and plays a protective role against cell death and apoptosis.20 SIRT3 also seems to play a protective role against cardiac hypertrophy and heart failure.35 Furthermore, SIRT3 is overexpressed in breast cancer, and it was shown to modulate p53 activity, preventing growth arrest and senescence in bladder carcinoma cells.19, 22 Because our current findings indicate that SIRT3 is overexpressed in OSCC tissues and cells (Fig. 1), we surmised that SIRT3 also plays a prosurvival role in oral cancer.