Reexpression of CAV1 or E-cadherin in CAV1 knockdown Ewing's sarcoma cells rescued the oncogenic phenotype of the original Ewing's sarcoma cells, showing that the CAV1/Snail/E-cadherin pathway plays a central role in the expression of the oncogenic transformation functions of EWS/FLI-1 [24]. The gene discussed is FLI1; the disease is Ewing sarcoma.