CAV1 expression was found to be absent or strongly reduced in 3 of 3 fibrosarcomas, 17 of 20 leiomyosarcomas, 5 of 8 angiosarcomas, 15 of 18 malignant fibrous histiocytomas, and 8 of 8 synovial sarcomas. Here, CAV1 is linked to leiomyosarcoma.