Alterations in the expression and activity of cardiac proteins that participate in the calcium handling, (e.g., calcium pump ATPase of sarcoplasmic reticulum (SERCA2), dephosphorylated phospholamban (PLN), which respectively decreases the affinity of SERCA2 for calcium, and sarcolemmal sodium calcium exchanger (NCX), which mediates calcium efflux from the cell [11] have been shown to occur in cardiomyopathy of STZ diabetic rats [12] and after MI [13]. The gene discussed is ATP2A2; the disease is cardiomyopathy.