It has been reported that an increased level of adrenocorticotropic hormone (ACTH) and cortisol can be associated with lethargy and hypertension before the onset of vomiting [12], and it has been hypothesized that corticotropin-releasing factor (CRF) may be a brain-gut mediator that directly connects stress and vomiting [13]. The gene discussed is POMC; the disease is Hypertension.