Further assessment of Aurora kinases and p53 interactions in cell lines or tissue specimens derived from precursor lesions of dysplasia (for ESCC) or intestinal metaplasia (for BAC) are necessary to disclose a causative role of Aurora kinases and p53 in the development of aneuploid, invasive esophageal cancers. This evidence concerns the gene TP53 and esophageal squamous cell carcinoma.