TP53 and esophageal cancer: In view of the role of p53 in post-mitotic cell cycle control, centrosome duplication and Aurora-A interaction [41-45,53] as well as its frequent mutation in esophageal carcinogenesis [4,10,11], we next determined p53 mutation status [54,55], p53 protein expression and intracellular localization [39] in the control EPC-hTERT cell line and in the four esophageal cancer cell lines (Figure 5).