LATS2 and colorectal cancer: For example, ectopic overexpression of functional Aurora-A in diploid colorectal cancer cell line [31] or ectopic expression of kinase deficient Aurora-A isoforms, which is unable to phosphorylate its substrate Lats2, in immortalized fibroblasts [32] both resulted in either supernumerary centrosomes, chromosome segregation defects and/or genomic instability.