HAVCR2 and diabetes mellitus: Our results were somewhat unexpected, given previous reports regarding Tim1, suggesting not only that the genes encoding Tim1 and Tim3 within the Tapr locus, along with their associated polymorphisms, may play a role in regulating pulmonary function [7] but that anti-Tim1 and anti-Tim3 antibodies administered in vivo exerted wide-ranging effects on T cell function during diabetes [20], transplant rejection [20], pulmonary inflammation [12], and EAE [21].