TRPA1 and Pallister-Hall syndrome: First, within the group of patients who suffered from paradoxical heat sensation (PHS) heterozygous and homozygous carriers of the TRPA1 710G>A variant were significantly under-represented as compared to neuropathic pain patients without PHS (odds ratio 0.44, 95% confidence interval 0.21–0.90, p = 0.03) (Fig. 1).