PTP4A3 and neoplasm: Subsequently, the relationship with clinicopathological factors was assessed for PRL-3 genomic amplification (Table 1), where it was significantly associated not only with its expression (P = 0.006), but also with depth of tumor invasion (P = 0.006), presence of LNM (P = 0.022), LNM status (P = 0.004 in JCGC, P = 0.002 in UICC), and stage (P = 0.005 in JCGC, P = 0.003 in UICC).