Taken together, our data show that offspring born to overtly obese dams fed a highlypalatable P diet beared a defective leptin signaling in hypothalamus, which remainedsilencious in pups weaned on the chow diet, thus without impact on theirpredisposition to develop obesity, a situation observed in fructose-fed rats [35] and in ourprevious study using a HF diet based on palm oil [22]. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.