The adoptive transfer of CD4+CD25+ T cells, which express higher amounts of Foxp3, but not of CD4+CD25− cells, significantly diminished the clinical signs of EAE for approximately 10 days, similar to the signs observed with P. chabaudi-infected mice 6 d.a.i. These results unequivocally demonstrated the central role of malaria-induced T regs in the control of EAE development. The gene discussed is CD4; the disease is malaria.