Similar to human pituitary adenomas, in the αGSU.PTTG pituitary gland, high PTTG levels result in aneuplody and chromosomal instability, also evidenced by DNA damage, pATM induction and activation of p53/p27 pathways known to arrest cell proliferation in the course of continuing DNA damage [39]. Here, PTTG1 is linked to pituitary gland adenoma.