As high clusterin expression was observed in benign gonadotroph adenomas and in small slow-growing αGSU.PTTG pituitary tumors (Figures 3 and 4E), and also in LβT2 cells overexpressing mPttg (Figure 5A,B), we analyzed the effects of altering intracellular clusterin levels. This evidence concerns the gene CLU and functioning gonadotropic adenoma.