In addition to EGF signaling, EGFR has been reported to be involved in theglucose transport by associating and stabilizing the active glucose transporter,SGLT1 [13],[20].Since the expression of EGFR was reduced by HDACi in CRC cells, the levels ofSGLT1 expression and intracellular glucose in response to HDACi were alsoexamined. Here, SLC5A1 is linked to colorectal carcinoma.