HDACfamily can be subdivided into four classes and the class I HDACs, which includesHDAC1, HDAC2, HDAC3 and HDAC8, have been reported to be highly expressed in coloncancer [16].The pro-proliferative effects of HDACs are connected to the transcriptionalrepression of cdk-inhibitor, p21, and knockdown of HDAC 1, 2 and 3 reduced thegrowth of several colon cancer cells [17]. Here, HDAC3 is linked to colonic neoplasm.