TP53 and scrapie: The cell lines from diverse origins were chosen: N2a neuroblastoma cells exhibit characteristics of neurons [48]; SMB-PS cells derived from scrapie-infected mouse brain but cured by in vitro treatment with pentosan sulfate are originated from the mesenchymal lineage [49]; CRBL cells derived from the cerebellum of p53 null mice show expression of both glial and neuronal markers [50]; and NIH 3T3 cells feature the characteristics of common fibroblasts [51].