In addition, although the pathogenic function of autoantibodies against Ro and La is not clear, a number of previous studies imply that enhanced pro-inflammatory cytokines, such as interferon (IFN)-γ, interleukin (IL)-18 and IL-17, are highly related to increased anti-Ro antibody levels in SS [6]. The gene discussed is CALR; the disease is synovial sarcoma.