Likewise, expression of the CAAT enhancer binding protein C/EBPalpha was particularly repressed with nuclear extracts of tumor tissue (see Figure 12A) while EMSA band shift (Figure 12B) assays confirmed its binding at gene specific promoters of Cav1, Foxc1, Defrc6, Itga4, EGF, Nr3c1,Sprr2i, TH and Zbtb7b, albeit at different levels. The gene discussed is CAV1; the disease is neoplasm.