Likewise, expression of the CAAT enhancer binding protein C/EBPalpha was particularly repressed with nuclear extracts of tumor tissue (see Figure 12A) while EMSA band shift (Figure 12B) assays confirmed its binding at gene specific promoters of Cav1, Foxc1, Defrc6, Itga4, EGF, Nr3c1,Sprr2i, TH and Zbtb7b, albeit at different levels. Here, ITGA4 is linked to neoplasm.