Appropriate experiments are warranted to examine global expression profiling and the extent of apoptosis in several tissues of a bigger cohort of Safb1-null/WrnΔhel/Δhel From the results of this study, we infer that an increased apoptosis together with a reduction in cell proliferation are likely to affect tumor promotion and overall aging in tissues of Safb1-null/WrnΔhel/Δhel mice. This evidence concerns the gene SAFB and neoplasm.