In HNSCC, let7-binding site polymorphism at 3'UTR of V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) (KRAS-LCS6) and sequence polymorphism in miR196A2 are both associated with reduced survival in head and neck cancer [119, 120]. The gene discussed is KRAS; the disease is head and neck squamous cell carcinoma.