Xi et al. found that miR-30a-5p, miR-181b, miR-372, let-7g, miR-26a, let-7b, miR-296, and miR30a-3p were upregulated by wt-p53, whereas miR-15b, miR-27a, miR200c, miR-191, miR-30c, miR-25, miR-107, miR-339, miR-125, miR-27b, miR-23a, and miR-10a were downregulated by wt-p53 in human colon carcinoma cell lines [36], suggesting that p53 plays a role in a wide range of miRNA expression. The gene discussed is TP53; the disease is colon carcinoma.